Pretty Fly gives a Big Fan item rather than a fly orbital, UNLOCK: Unlock this by defeating Mega Satan as Tainted Eve, 1 Dot - Rerolls all of your items. Counts as 1 of 3 angel items needed towards the Seraphim transformation. Counts as 1 of 3 evil items needed towards the Leviathan transformation. grey, gray, green, mouth, bobs rotten head, bob rotten head, Teleports Isaac to a random location on the map, Can't be used to teleport to the I AM ERROR room, REPENTANCE - Teleport! You're gonna have to Google the id on the wiki however by looking up the item. When you take damage and the cannon breaks, you take an additional 2 full hearts of damage and gain the Anemic effect for the room. UNLOCK: Unlock this item by defeating Ultra Greed as Apollyon, At the start of each new hostile room, you have a 20% chance to gain a random charmed familiar which will fight for you, The charmed enemy has its own health bar and will die if it takes enough damage, Charmed enemies persist between each room and floor for as long as they stay alive, Allows you to have more than one charmed familiar at a time if you can keep them alive, * pokemon, phone, black, green, blue, gps, Every time one of your tears hits an enemy, it has a chance to start bleeding, which will cause it to take damage every 5 seconds, The bleed damage dealt by BackStabber is based on how quickly an enemy is moving (faster enemies take more damage), Damaging enemies from behind gives the bleed effect a 100% chance to apply, While an enemy bleeds, they leave behind creep that damages other enemies, The tear that inflicts the bleed effect also deals double damage, *, knife, dagger, red, heart, silver, knife, When used, Sharp Straw will deal damage to all enemies in the room, The damage dealt is equal to Isaac's current tear damage plus 10% of the enemy's max health, Every time this item deals damage, it has a 15% chance to drop 1/2 red hearts, REPENTANCE - Sharp Straw is now only able to generate half red hearts (previously, it generated half soul hearts if the player had no heart containers), A razor blade orbital that deals contact damage and applies the bleeding status effect to enemies and bosses, which will cause them to take damage every 5 seconds, The contact damage dealt by Mom's Razor is based on how quickly an enemy is moving (faster enemies take more damage), Its speed is not affected by the Guardian Angel item, An eye orbital that shoots tears that deal 3.5 damage and deals 2 contact damage per tick to enemies, The damage dealt by this orbital does not scale with damage upgrades, REPENTANCE - Bloodshot Eye now blocks enemy shots, has increased shot speed and rate of fire, and now only shoots when lined up with enemies, When used, spawns a charmed random white delirium version of a boss, that will fight for you and kill other enemies for the rest of the current room, Possible bosses spawned include most bosses in the game, Some bosses' effects can harm Isaac. At +0 Luck theres a ~2.5% chance for this effect to activate, The size of the rift scales with your tear damage, In Antibirth this item was called Oculus Rift, A familiar boil that randomly fires bursts of tears, similar to the Boil enemy, A familiar baby that fires tears which have a chance to freeze or petrify enemies, When used, rerolls all items in the room into another random item from the current room's item pool, however the item also has a 30% chance to disappear, The chance associated with this item does NOT scale with your Luck stat - it's always 30%, In the game files this item is called 'Florians Dice', which is a reference to the Eternal update for the original Binding of Isaac game, which changed the D6 to act as this item does. The item order is based on the original The Binding of Isaac up to item 129 ( A Lump of Coal ), and its expansion, Wrath of the Lamb, up to item 195 ( Box ). the eternal hearts that drop in angel themed super secret rooms, All heart drops from Ace of Hearts will be Black Hearts, UNLOCK: Unlock this item by beating Satan with Azazel, *, black, devil, pointy, daemons tail, demons tail, demon tail, Dying in a sacrifice room while holding this trinket will unlock The Lost character, After The Lost is unlocked, dying anywhere with this trinket will bring you back to life as The Lost and the trinket will be deleted, When playing as Tainted Lost, you don't swap to being regular Lost, it simply acts as an extra life, UNLOCK: Unlock this item by beating Dark Room with Isaac, Everytime you pick up a coin, you fart, inflicting poison damage to nearby enemies, Greatly increases the chance of coins dropping from poops, Tears now move forwards at right angles, shifting left and right across the room, Increases your range stat by +10.0 while held but due to the fire pattern, your tears travel a similar distance to normal, Your tears now whip across the room at a very high shot speed, Shot speed gives your tears more effective range, but doesn't increase your range stat directly, Has a 22.22% chance to respawn with 3 Soul hearts as Blue Baby when you die, UNLOCK: Unlock this item by beating Satan with Lazarus, Everytime Isaac takes damage, one blue fly will spawn, * , the lost item pool, green, red, bloody, dead, Isaac's tears have a chance to poison enemies, The poison effect leaves a damage over time, which deals 4 or 6 damage per tick, The chance to poison enemies is affected by your luck stat and at +18 Luck it will activate every time, Isaac now has a chance to make a spectral and piercing tear, The chance to fire a piercing tear is affected by your luck stat and at +18 Luck it will activate every time, While held, this trinket gives a random mushroom effect each room, Possible mushrooms include: Mini Mush, Odd Mushroom (Thin), Odd Mushroom (Thick), The Compass, *, ping, pong, paddle, grey, gray, mushroom, While at 1/2 a red heart of health, you gain a Little Steve familiar that follows you and shoots homing tears, REPENTANCE - Umbilical Cord now has a high chance to spawn a Gemini familiar for the room when Isaac takes damage. sack, pouch, blue, purple, Tears gain a damage up and increase in size based on the distance they travel, The length of a normal room roughly gives +6 damage, but this can be higher with double rooms or Tiny Planet, This item synergises with beam items such as Brimstone and Tech, allowing them to do more damage the further away the enemy is, When used, removes one heart container and gives you 3 soul hearts, Item Pool: Devil Room, Curse Room, Red Chest, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, UNLOCK: Unlock this card by opening Mom's Box on the Home floor. No longer has an "on hit" effect, UNLOCK: Unlock this item by donating 999 pennies to the Shop, * shop room pool, shop item pool, stopwatch, blue, pocket, clock, Tears now revolve around Isaac's Body at a fixed distance until they hit the ground, Aiming in the opposite direction is often better due to how the tears circle around Isaac, Causes a lot of great synergies with items such as Lump of Coal, Brimstone, Rubber Cement, Technology and most of the worm trinkets, REPENTANCE - Tiny Planet's orbit now more tightly follows Isaac. Searching for the items name is gonna give you the . The Rosary Bead changes this to a 75%/25% chance of an angel or devil room (respectively), When Isaac takes damage, there is a chance he will gain the Gamekid effect, turning him invincible and dealing contact damage to any enemies he touches, The chance to activate the invincibility effect is affected by your luck stat and at +38 Luck it will activate every time you get hit, * , the lost item pool, nes, game, grey, gray, Tears shrink and grow in size as they go across the room, Does not appear to affect your damage and only the hitbox size of tears, Tears now move in a wave fashion across the room, While held, tears move in a spiral pattern across the screen at high speed, Effectively increases your range due to the tear pattern, Tears become flat and disc shaped giving them a larger hitbox, While this trinket is held, all items in the Shop cost 0 coins, After buying any 0 cent item in the Shop, the trinket disappears, UNLOCK: Unlock this item by beating the Chest with Lazarus, *, grey, gray, dollar, bill, note, cash, money, Isaac no longer takes damage from walking over spikes and blood creep while this trinket is held, * , the lost item pool, brown, pink, lump, ball, spot, 33% chance to drop a coin for every rock that you destroy, REPENTANCE - Previously was 100%, now 33%, UNLOCK: Unlock this item by destroying 100 rocks, Mom's Leg will now appear every 20 seconds and stomp down randomly in the room dealing 300 damage to enemies. Will take red hearts first before any other, Eve starts with this item after donating 439 coins to the Greed Donation Machine, UNLOCK: Unlock this item by beating Satan with Eve, Item Pool: Item Room, Curse Room, Demon Beggar, * devil pool, devil room pool, devil deal, the lost item pool, starting, silver, grey, gray, Upon use, this item refreshes the current floor with brand new rooms, monsters and items, as if you had entered a new floor, UNLOCK: Unlock this item by beating Satan with Blue Baby, Item Pool: Item Room, Secret Room, Devil Room, Demon Beggar, * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, Teratoma, Envy) then Meat Cleaver will deal a lot of damage and trigger the splitting effect, If the split enemy has low enough health, it will just die instead of splitting, Doesn't work on end-game bosses except Delirium, where it will deal a chunk of damage and spawn a 2nd Delirium to deal with, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Isaac, You no longer take damage from poison/toxic gas/burn effects, and become immune to fear/confusion, This item isn't available in any item pools - you are automatically given it after defeating Dogma, just before The Beast sequence, Grants a one-time use of the Holy Mantle effect, On normal mode this grants The Wafer effect, causing all damage to do a maximum of half a heart each time, Sets your health to 6 hearts if you have fewer than 6. * e coli, item room, treasure room, item room pool, tampon, bloody, red, white, red sperm, ecoli, Isaac's tears turn into large scythes that pierce through enemies (Similar to how Death's scythes look), UNLOCK: Unlock this item by beating Challenge #17 (Waka Waka), * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, axe, silver, *, mustache, moustache, white, yellow, moms toenail, Increases the chance for Black hearts to spawn, UNLOCK: Unlock this item by beating the Dark Room with Eve, * , the lost item pool, grey, gray, makeup, Gives you a higher chance of eternal hearts, Contrary to popular belief, the Bible Tract doesn't allow Angel Rooms to appear after paying for a Devil Deal, * , the lost item pool, grey, gray, black, book, Allows you to unlock golden chests without needing a key, Cain starts with this trinket after donating 68 coins to the Greed Donation Machine, When you reach half a heart of life remaining, a black heart will spawn, After three black hearts have spawned, the trinket dissapears, * , the lost item pool, hand, brown, monkeys paw, monkey's paw, Imitates the behaviours of some of the other 'paper' items/trinkets, A Missing Page: When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect, Has a chance to trigger the Polaroid or Negative effect every time you take damage with half a red heart or less, Missing Poster: Dying in a sacrifice room while holding this trinket will reveal a puzzle piece on the death screen. Curse of the Lost), Black Candle removes the teleportation effect of Cursed Eye, +15% chance of a devil or angel room opening after the boss fight, UNLOCK: Unlock this item by donating 150 pennies to the Shop, * curse room pool, shop room pool, shop item pool, grey, gray, Gives Isaac high damage tears with a short range, Tear size and damage falls off very fast with this item, the further the tear travels the less damage it does, Tear damage starts at triple (300%) and decreases over range to eventually be 0%, * item room, treasure room, item room pool, red, bloody, eyeball, If the total sum of all your health is at one heart after taking damage, the necronomicon effect will activate, dealing 40 damage to the entire room, REPENTANCE - Missing Page 2 now doubles all black heart and Necronomicon damage (to 80 instead of the usual 40), Item Pool: Devil Room, Demon Beggar, Secret Room, * demon beggar pool, demon judgement pool, devil beggar pool, secret room pool, devil pool, devil room pool, devil deal, the lost item pool, red, bloody, purple, paper, A yellow orbital fly that will block shots and when Isaac gets hit, will seek out the nearest enemy and attack it, If the fly is in its attacking state and there are no longer any enemies in range, it will return to Isaac and go back to being a defensive orbital, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, 23 days ago. with Brimstone it fires 10 lasers), Turns your tears into bones, which shatter into 1-3 smaller bone shards upon hitting any object or enemy, The smaller bone shards deal damage equal to half your normal tear damage, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Lazarus, Allows Isaac to carry two cards, runes or pills (or any combination of these) at the same time, Drops a random card, pill or rune on pickup, UNLOCK: Unlock this item by beating Greedier Mode with The Lost, Item Pool: Boss Room, Beggar, Gold/Stone Chest, *, silver, metal, grey, gray, omega, dads lost coin, dad lost coin, dad coin, REPENTANCE - This was renamed from Moldy Bread, *, sandwich, toast, brown, green, bite, bitten, Each time you take damage from any source, Cone Head has a 20% chance to prevent it from reducing your health, Isaac flashes blue very briefly when damage is negated by this item, * northernlion, nl, northern lion, ryan letourneau, egg, egg father, egg daddy, dad, BALD, northernlion's head resembles an egg much like this item, isn't that hilarious?, pink, Isaac's tears have a 20% chance to be a booger instead, which stick on to enemies and deal periodic poison damage until they die, Each tick of poison damage is equal to your normal tear damage, Each booger persists for 10 seconds or until the enemy dies. The priority list of what will drop from champion enemies in order is as follows: Soul Hearts - When you have no red heart containers and less than 2 soul hearts, Red Hearts (Full hearts) - While at 0.5 red hearts, Red Hearts (Full hearts) - When you have at least half a red heart container empty, Trinkets - If you have no trinkets and there are no trinkets on the ground in the room, Soul Hearts - When you have less than 6 total heart containers of any kind, If none of the above conditions are true, champions will resume dropping their regular pickups, UNLOCK: Unlock this item by defeating Greedier mode with Maggy, Allows you to fire tears diagonally by holding down two of the fire buttons at once, If you are using a gamepad, this item allows you to fire in any direction, The first enemy you kill in each new room will now explode and poison all nearby enemies, causing them to take periodic damage until they also die and explode, If you have lots of enemies near each other this can cause a chain reaction, killing lots of enemies in one go, Gives Isaac a finger which floats infront of him and points in the same direction he is facing or firing. item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Drops a random trinket on the floor when picked up, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag, All of Isaac's bombs now leave a poison effect on any enemies within the blast radius, As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick, Has a chance to drop from the Super Sloth miniboss fight.
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